Satoris Discovery Process

The processes of neuroinflammation and neurodegradation occurring in the brain in Alzheimer’s disease are associated with cells and cell-signaling proteins capable of crossing the blood-brain barrier. Satoris scientists postulated that a particular disease state would produce a characteristic pattern of such cell-signaling proteins.

This was confirmed by studying the expression levels of more than 220 signaling proteins in both Alzheimer’s disease (AD) patients and normal controls. At least 45 markers showed distinct differences between the groups, and a subset of 18 markers were identified that discriminated between AD and normal and/or other dementias, with 90 percent accuracy, and up to two years earlier than conventional diagnostic procedures.

This novel approach of studying signaling protein signatures is also expected to have application in other neurological diseases.